Miles Dieffenbach: Inside Carnegie Mellon’s $4BN Endowment & The Hidden Math Behind DPI, TVPI, and Illiquidity

20VC

Aug 4, 2025

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Miles Dieffenbach is Managing Director of Investments at Carnegie Mellon University, where he helps oversee a $4 billion endowment with a focus on venture capital, private equity, and alternative investments. Under his leadership, CMU’s private book has remained self-funding during some of the toughest years for liquidity.

Agenda for Today:

– “I Had Cancer at 26 — It Changed Everything”

– Inside the $4BN Carnegie Mellon Endowment: The Investment Blueprint

– Are LPs Getting Screwed in Venture?

– 90% of LPs Shouldn’t Be in Venture — Here’s Why

– Seed Funds Are a Trap (And No One Wants to Admit It)

– The $140BN Problem with Multi-Stage Funds

– “Index Is the Best in the Game — Here’s Why They Win”

– “The Dirty Secret of LPs: Brand Over Performance”

– “When Founder-Friendly Goes Too Far”

– “The OpenAI Bubble — Will It All Go to Zero?”

– “Ping Pong Diligence & Wildest Fundraising Stories”

https://open.spotify.com/episode/6OCq8WPsCV44ymC1vM4CqF?si=354703cd05da4600

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